It is possible to connect to the Nethermind node using web3.py (python web3.js implementation). You will need to have web3.py installed using following guides:
You may use below script in order to check your connection. Please make sure you have enabled JSON RPC module, this can be done by passing flag --JsonRpc.Enabled true to either Nethermind.Launcher or Nethermind.Runner
from web3.auto import w3
connected = w3.isConnected()
print(connected)
if connected and w3.clientVersion.startswith('Nethermind'):
client = w3.clientVersion
print(client)
else:
client =None
print(client)
You should see the following output (depends on the node version):